TPM1 — Tropomyosin 1
TPM1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TPM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Surface colonocyte differentiation Epithelial development | AGR3, ATP1B1, BMP3, CLDN3, DSP, KLF5, KRT20, NEURL1B +2 more | View in SCUBA |
| Fibroblasts | Myofibroblast Contractile Cytoskeletal | ACTA2, CCDC107, CFL2, CSRP1, FLNA, ILK, LPP, MSRB3 +7 more | View in SCUBA |
| Goblet cells | Mucin O-Glycosylation Mucus production & secretion | ACLY, ASPH, C9orf152, CKAP4, ESRP1, FABP2, IL13RA1, PLPP5 +8 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Differentiation Erythropoietic | DHRS11, DNAJC6, EPOR, FHL2, GATA1, HBD, KLF1, LXN +5 more | |
| Pericytes | Smooth Muscle Contractile Cytoskeletal | ACTA2, CSRP1, FLNA, MYL9, MYLK, NEXN, PPP1R14A, S100A4 +2 more | View in SCUBA |
| Smooth muscle cells | SMC Contractile Apparatus Contractility | ACTG2, CFL2, CKB, CSRP1, FLNA, ILK, LMOD1, MYH11 +3 more | View in SCUBA |
About the gene
| Synonyms | C15orf13, CMH3 |
|---|---|
| Chromosome | 15: 63042632-63071915 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Actin-binding, Muscle protein |
Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.