Matrisome Regulators
Gene co-expression module in Smooth muscle cells
| Category | ECM remodeling |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hubs are secreted matrix-modulating proteins: NBL1 (DAN-family BMP antagonist), TIMP2 (MMP inhibitor), LUM (small leucine-rich proteoglycan), PMP22/LPP (membrane and adhesion/cytoskeletal linkers), with ITM2C, S100A13, TMEM176B as broadly expressed secretory/membrane genes. The profile is a low-level, uniformly detected matrisome-regulator program typical of the fibroblast-like/synthetic end of the colonic mural cell spectrum, and it sits in a neighborhood dominated by collagen synthesis (M108) and fibroblast matrisome (M26) modules, supporting an ECM-regulation reading rather than contraction or contamination.
Genes
ITM2C, LPP, LUM, NBL1, PMP22, S100A13, TCEAL4, TIMP2, TMEM176B, TUBA1A
Most correlated modules
- Collagen Biosynthesis · correlation 0.89
- Wnt-Hedgehog Niche · correlation 0.87
- Fibroblast Matrisome · correlation 0.85
- Adhesion Activation · correlation 0.82
- Collagen-Laminin Deposition · correlation 0.79
- Notch-TGFbeta Signaling · correlation 0.78
- Basement Membrane Matrix · correlation 0.77
- FOXF2 Mesenchymal Patterning · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.