FBLN1 — Fibulin 1
FBLN1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FBLN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | Stromal ECM Production ECM production | ABCA8, CCL11, CFD, CTSK, DCN, LUM, MFAP4, VCAN | View in SCUBA |
| Smooth muscle cells | Fibroblast Matrisome ECM remodeling | ADAMDEC1, EMP1, LTBP4, NR2F1, PLTP, PROCR, RGS10, S100A10 +1 more | View in SCUBA |
About the gene
| Synonyms | FBLN |
|---|---|
| Chromosome | 22: 45502238-45601135 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Host-virus interaction |
Function
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.