PSMG2 — Proteasome assembly chaperone 2
PSMG2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PSMG2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Cellular Housekeeping Housekeeping | ACAT2, ACOT7, CISD2, FDPS, NUDT21, PA2G4, PPIA, PSMC3 +9 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7 +37 more | View in SCUBA |
| Macrophages | Spliceosomal snRNP Cell cycle | ANAPC11, BANF1, CCDC25, CCT8, ERH, FIBP, FKBP3, GLRX5 +30 more | View in SCUBA |
| Smooth muscle cells | hnRNP & Proteasome RNA processing & translation | ARF1, CCT2, GDI2, HNRNPA2B1, HNRNPA3, HNRNPF, HNRNPU, PSMD8 +2 more | View in SCUBA |
About the gene
| Synonyms | CLAST3, HCCA3, HsT1707, MDS003, MGC15092, PAC2, TNFSF5IP1 |
|---|---|
| Chromosome | 18: 12658043-12728945 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Chaperone |
Function
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.