Vascular Matrix Secretion
Gene co-expression module in Smooth muscle cells
| Category | ECM remodeling |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
Dominated by secreted matrix proteins of mural cells: BGN (small leucine-rich proteoglycan) and MGP (matrix Gla protein, inhibitor of vascular calcification), with TRIM47 (vascular mural/endothelial), HSPB7 (muscle small heat-shock protein stabilizing the cytoskeleton), ARPC1B and RAB13 (actin branching/trafficking). The module is a vascular/mural matrix-secretion program with a minor cytoskeletal component; its neighbors M11 and M73 are also mural matrix/identity modules, supporting an ECM-secretory rather than inflammatory reading.
Genes
ARPC1B, BGN, CALHM2, HSPB7, MGP, MXI1, RAB13, TRIM47
Most correlated modules
- Basal Metabolic Housekeeping · correlation 0.83
- Mitochondrial Housekeeping · correlation 0.80
- Ubiquitous Housekeeping Transcripts · correlation 0.79
- Myogenic Cytoskeletal Program · correlation 0.79
- OXPHOS Complex I · correlation 0.76
- Pericyte Notch Identity · correlation 0.75
- Contractile SMC Identity · correlation 0.75
- Glucocorticoid Metallothionein Response · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.