Mitotic Spindle
Gene co-expression module in Colonocytes
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 17 of 17 genes have a known function matching the annotation |
Why this annotation
All 17 genes are canonical late mitosis/M-phase markers: MKI67 (mitosis marker), TOP2A (topoisomerase II, chromosome segregation), BIRC5/survivin (chromosomal passenger complex), CDC20 (APC/C activator, metaphase-anaphase transition), CDKN3 (CDK phosphatase), CCNB1/CCNB2 (cyclin B1/B2, M-phase cyclins), MAD2L1 (spindle assembly checkpoint), TPX2 (spindle assembly), PTTG1/securin (sister chromatid separation), CENPE (kinetochore motor), UBE2C (APC/C ubiquitin ligase), TROAP (mitotic spindle), PRR11 (mitosis), CENPF (kinetochore), SAPCD2, CKAP2 (spindle). This is a tightly coherent late mitosis/spindle assembly checkpoint module. Together with M71 and M72, this batch neighborhood represents the full cell cycle proliferative program.
Genes
Most correlated modules
- G2/M Mitotic Entry · correlation 0.91
- DNA Replication S-phase · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.