CDKN3 — Cyclin dependent kinase inhibitor 3
CDKN3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDKN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | G2/M Mitosis Cell cycle | AURKA, BUB1, CCDC34, CCNB1, CCNB2, CDC20, CENPA, DLGAP5 +7 more | View in SCUBA |
| CD8⁺ T cells | CDK1-Aurora Kinase Mitosis Cell cycle | AURKB, BIRC5, CCNA2, CDK1, CKS1B, KIF22, KIFC1, MAD2L1 +2 more | View in SCUBA |
| Endothelial | NF-κB Oxidative Stress Stress | ACP1, ALDH7A1, ARHGDIB, CCDC85C, CDC25B, CMSS1, COPRS, CYTL1 +13 more | View in SCUBA |
| Goblet cells | Mitotic Spindle Assembly Cell cycle | ARHGAP11A, AURKA, CENPA, CKAP5, CKS2, FAM83D, KIF14, KNL1 +5 more | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Cell cycle | BIRC5, CCNB2, CDC20, CEP55, DLGAP5, HMMR, MKI67, TPX2 +1 more | |
| Macrophages | Mitotic Spindle Cell cycle | ANLN, ASPM, AURKA, BIRC5, CCNA2, CCNB1, CCNB2, CDK1 +14 more | View in SCUBA |
About the gene
| Synonyms | CDI1, KAP |
|---|---|
| Chromosome | 14: 54396849-54420218 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
| Biological process | Cell cycle |
Function
May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.