G2/M Mitotic Entry
Gene co-expression module in Colonocytes
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 20 of 37 genes have a known function matching the annotation |
Why this annotation
Hub genes include LMNB1/LMNB2 (nuclear lamins, G2/M), PCLAF (PCNA-associated, S/G2), UBE2S/UBE2T (ubiquitin-conjugating enzymes active in mitosis), RRM1 (ribonucleotide reductase, S-phase), DTYMK (thymidylate kinase, nucleotide synthesis), MIS18A (centromere assembly), SKA2 (spindle/kinetochore), RAD51AP1 (homologous recombination), HMGB2 (chromatin remodeling in proliferating cells), CKS2 (CDK regulatory subunit), TYMS (thymidylate synthase), ZWINT (kinetochore), SMC4 (condensin), TK1 (thymidine kinase), CENPM (centromere protein). This is a G2/M transition and mitotic entry module, complementary to M71 (S-phase) and M106 (late mitosis). Enriched in crypt_colono, consistent with proliferating crypt progenitors.
Genes
Most correlated modules
- Mitotic Spindle · correlation 0.91
- DNA Replication S-phase · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.