TMEM107 — Transmembrane protein 107
TMEM107 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM107's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic Effector CD4 Cytotoxicity | ADAM8, ADRB2, CCL5, CHD9, DPP4, HIC1, HOPX, IFIT2 +13 more | View in SCUBA |
| Gamma-delta T cells | AP-1 Immediate Early Response Stress | BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B +25 more | |
| Innate lymphoid cells | Dissociation Stress Response Stress | C12orf57, CA2, CALM2, EHD1, EIF4A2, IER2, MEPCE, NDRG1 +9 more | View in SCUBA |
| Mucosal-associated invariant T cell | AP-1 Immediate Early Stress | AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, H2AX +17 more |
About the gene
| Synonyms | JBTS29, MGC10744, MKS13 |
|---|---|
| Chromosome | 17: 8172457-8176399 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Cilium biogenesis/degradation |
Function
Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.