SRSF7 — Serine and arginine rich splicing factor 7
SRSF7 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SRSF7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA Splicing Processing RNA processing | ANXA2R, APOL3, BTN3A1, CCNL1, CHCHD7, CMPK1, DDX5, EIF4A2 +7 more | View in SCUBA |
| CD8⁺ T cells | Pre-mRNA Splicing RNA processing & translation | BRD2, EIF3A, FUS, HNRNPU, HSPA9, NCL, PNN, RBM25 +5 more | View in SCUBA |
| Fibroblasts | Fibroblast Quiescence Housekeeping | BTG1, EIF1, EIF4A2, FNIP1, ID2, KLF2, KLF4, RHOB +5 more | View in SCUBA |
| Gamma-delta T cells | ER Proteotoxic Stress Stress | ARL4A, BCAS2, CCDC59, CSRNP1, CYCS, EIF5, EXOSC6, FOSB +13 more | |
| Glial cells | Hypoxia mTOR Stress Stress | AMD1, CDKN2AIP, CITED2, DDIT4, HEXIM1, HSPA2, IFRD1, INTS6 +3 more | View in SCUBA |
| Innate lymphoid cells | Immediate Early Response activation | ATF3, BRD2, BTG2, CCNL1, DDX3X, DNAJA1, EGR1, EIF4A3 +8 more | View in SCUBA |
| Monocytes | ER Stress Response Stress | CDKN1B, CFAP20, DDIT3, GIMAP5, HSPA5, KLF2, KLF4, ODC1 +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | Dissociation Stress Response Stress | DUSP1, EIF1, FOS, H3-3B, IER5, SAT1, SRSF3 |
About the gene
| Synonyms | 9G8, AAG3, HSSG1, RBM37, SFRS7, ZCCHC20, ZCRB2 |
|---|---|
| Chromosome | 2: 38743599-38751494 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Repressor, RNA-binding |
| Biological process | mRNA processing, mRNA splicing, mRNA transport, Transport |
Function
Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1- NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA- binding activity. RNA-binding is semi-sequence specific.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.