PRR13 — Proline rich 13
PRR13 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRR13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Actin Cytoskeleton Cytoskeletal | COTL1, GNAI2, HIGD2A, MOB1A, MPG, MYL12A, MYL12B, NDUFB5 +8 more | View in SCUBA |
| CD4⁺ T cells | Cytoskeleton & metabolism Cytoskeletal | ATP5F1D, ATP5MC3, ATP6V0E1, BRK1, CAP1, LCK, MYL6, NEDD8 +11 more | View in SCUBA |
| Enterocytes | Lysosomal/ferritin housekeeping Housekeeping | APLP2, CD164, CRIP1, CST3, EDF1, FTH1, FTL, GPA33 +5 more | View in SCUBA |
| Gamma-delta T cells | ER-Lysosomal Trafficking Protein processing & ER | ARL6IP5, ATF6B, BORCS6, CD53, CLN3, DHRS7, MGAT1, MMP23B +12 more | |
| Innate lymphoid cells | Lipid & Isoprenoid Metabolism Metabolism | ARL6IP1, CHCHD5, ECH1, FDPS, GTF2H5, LYPLA1, NECAP2, NUBP2 +8 more | View in SCUBA |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1 +20 more | View in SCUBA |
About the gene
| Synonyms | DKFZP564J157, FLJ23818 |
|---|---|
| Chromosome | 12: 53441678-53446645 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.