RHEB — Ras homolog, mTORC1 binding
RHEB belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RHEB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chaperone Proteostasis Protein processing & ER | BANF1, CCT3, CCT4, CCT5, FXR1, HNRNPH3, HSPB1, MAGOH +7 more | View in SCUBA |
| Gamma-delta T cells | G1/S Entry Cell cycle | CDKN2A, CKS2, CMC2, H2AZ1, H2AZ2, HMGB2, IFI27L1, KPNA2 +15 more | |
| Glial cells | Glial Cytoskeletal Homeostasis Cytoskeletal | ARL6IP5, CD99, CNP, CSRP1, FEZ1, SCCPDH, TBCB, VWA1 | View in SCUBA |
| Innate lymphoid cells | Proteasome ER Proteostasis Protein processing & ER | ATP5MC1, ATP5PF, DBI, GNG5, GTF3C6, HNRNPK, IL4I1, MANF +19 more | View in SCUBA |
| Lymphatic endothelial | NF-κB Negative Feedback Inflammation | BMP2, C2CD4B, ICAM1, IRF8, KLF6, MAFF, NFIL3, NFKBIA +4 more | View in SCUBA |
| Macrophages | RAS-MAPK Signaling Housekeeping | ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1 +26 more | View in SCUBA |
| Smooth muscle cells | Proliferative Biosynthesis Housekeeping | ARF5, BUB3, CBX5, DCTN3, DUT, HMGN2, IDH2, KRTCAP2 +7 more | View in SCUBA |
About the gene
| Synonyms | RHEB2 |
|---|---|
| Chromosome | 7: 151466012-151520120 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes. In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1. Has low intrinsic GTPase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.