IL33 Alarmin Signaling
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub gene IL33 is a canonical endothelial alarmin cytokine released during inflammation. Supporting genes include PTAFR (platelet-activating factor receptor, inflammatory lipid signaling), DOC2B and SDCBP (vesicle secretion machinery relevant to cytokine release), MCUB and SLC8A1 (mitochondrial and plasma membrane calcium handling, linked to inflammatory activation), STMN3 (microtubule dynamics), ARHGAP26 and CHN1 (Rho GTPase regulators). The module is upregulated in CD inflammation and reversed in UC remission, consistent with an endothelial alarmin/inflammatory activation state. IL33 is the dominant hub and defines the program.
Genes
ARHGAP26, CHN1, DOC2B, IL33, MCUB, PTAFR, SDCBP, SLC8A1, STMN3, TSPAN7
Most correlated modules
- Venular Inflammatory Activation · correlation 0.90
- Arterial EC Identity · correlation 0.88
- Macrophage Contamination · correlation 0.85
- Leukocyte Recruitment Signaling · correlation 0.85
- Myeloid Contamination · correlation 0.82
- Venous EC Identity · correlation 0.80
- Angiogenic Metabolic Adaptation · correlation 0.79
- Translation Elongation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.