Endothelial Barrier Homeostasis
Gene co-expression module in Endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
This module is significantly downregulated in both UC and CD inflammation and recovers in remission, consistent with a homeostatic endothelial program lost during active disease. Hub genes include JAM2 (junctional adhesion molecule, endothelial barrier), LSR (lipolysis-stimulated lipoprotein receptor, tight junction), AFDN (afadin, adherens junction), and ITGB4 (integrin beta-4, basement membrane adhesion). LIFR and IL6R indicate cytokine receptor expression on quiescent endothelium. NKX2-3 is a transcription factor marking intestinal endothelium. CLEC3B (tetranectin) and ENPP2 (autotaxin) are secreted factors associated with vascular homeostasis. TNFRSF1B and IFNGR1 are inflammatory receptors present at baseline. The overall signature points to a quiescent, barrier-competent intestinal endothelial state with junctional integrity. Neighbor context: complements M10's vascular identity program, together defining homeostatic endothelial states.
Genes
AFDN, CD2AP, CLEC3B, ENPP2, IFNGR1, IL6R, ITGB4, JAM2, LIFR, LSR, MFSD4A, NKX2-3, RAMP1, SELENBP1, SLFN5, ST6GALNAC1, SYNGR2, TERF2IP, TNFRSF1B, TPO
Most correlated modules
- Vascular EC Identity · correlation 0.80
- NF-kB Chromatin Regulation · correlation 0.72
- Quiescent EC Identity · correlation 0.68
- MHC Class I Presentation · correlation 0.66
- MHC Class II Presentation · correlation 0.61
- Type I Interferon Response · correlation 0.58
- TRAIL-mediated Apoptosis · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.