ER Calcium Stress
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
WDR1 (AIP1, cofactor for cofilin-mediated actin disassembly) links this module to the actin remodeling neighborhood (M106, M51). RCC2 regulates RanGTP and microtubule dynamics. ATP2A2 (SERCA2) and CALU are ER calcium-handling proteins. ELOVL5 and ACOT7 are fatty acid metabolism enzymes. UFD1 and PSMD7 are ubiquitin-proteasome pathway members. GTF2A2 is a basal transcription factor. LYAR is a nucleolar protein. The module is functionally mixed but the strongest inflammation signal in the batch (delta UC 0.46, CD 0.38) and reversal in remission suggest a stress-coupled housekeeping response. The ER calcium + actin disassembly combination is consistent with cytoskeletal stress in inflamed endothelium.
Genes
ACOT7, ATP2A2, CALU, ELOVL5, GTF2A2, LYAR, PSMD7, RCC2, UFD1, WDR1
Most correlated modules
- Actin Vesicle Trafficking · correlation 0.94
- Proteasomal Degradation · correlation 0.91
- Rho-Actin Remodeling · correlation 0.91
- Actin Cytoskeletal Remodeling · correlation 0.90
- Inflammatory Lipid Metabolism · correlation 0.89
- Mitochondrial OxPhos · correlation 0.88
- mRNA Splicing Stress · correlation 0.88
- Glycolysis Activation · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.