Mitochondrial OxPhos
Gene co-expression module in Endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes NDUFA4, COX7A2, COX7B, NDUFS5, NDUFA11, COX6A1, UQCRQ, NDUFB3, NDUFA6 are all subunits of mitochondrial respiratory chain complexes I, III, and IV. TIMM8B supports mitochondrial protein import. The module is tightly coherent with core membership for most hub genes, uniformly expressed, and upregulated in IBD inflammation — consistent with increased metabolic demand or mitochondrial stress in inflamed endothelium. PSMB3/PSMA5 (proteasome) and ELOB may reflect coupled protein quality control. This is a canonical OxPhos module.
Genes
ARPC3, CLTB, COX6A1, COX7A2, COX7B, DAD1, ELOB, MYL12B, NDUFA11, NDUFA4, NDUFA6, NDUFB3, NDUFS5, PSMA5, PSMB3, TIMM8B, UBL5, UQCRQ
Most correlated modules
- Mitochondrial OxPhos · correlation 0.95
- Glycolysis Activation · correlation 0.90
- Respiratory Chain Complex · correlation 0.89
- ER Protein Processing · correlation 0.88
- Housekeeping Metabolic · correlation 0.88
- ER Calcium Stress · correlation 0.88
- mRNA Splicing Stress · correlation 0.87
- Proteasomal Degradation · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.