Proteasomal Degradation
Gene co-expression module in Endothelial
| Category | Protein processing & ER |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Four proteasome subunits dominate: PSMB5 (20S beta-5, chymotryptic active site), PSMA1 (20S alpha-1), PSMD2 (19S regulatory lid), PSMC1 (19S ATPase). These are core components of the ubiquitin-proteasome system. Supporting genes include PON2 (antioxidant, protects against oxidative protein damage), TKT (pentose phosphate pathway, NADPH for redox balance), NUDT5 (nucleotide pool maintenance), MRPL36 (mitochondrial ribosome), NME4 (nucleoside diphosphate kinase), HACD3 (fatty acid elongation), GNL3 (nucleolar GTPase involved in ribosome biogenesis), TMEM167A. The proteasome genes are the clear hub. Upregulation in inflammation is consistent with increased protein turnover and ERAD demand. Neighbor M121 (UPR/ER stress) directly feeds misfolded proteins into the proteasome via ERAD, explaining co-expression network proximity.
Genes
GNL3, HACD3, MRPL36, NME4, NUDT5, PON2, PSMA1, PSMB5, PSMC1, PSMD2, TKT, TMEM167A
Most correlated modules
- mRNA Splicing Stress · correlation 0.93
- Glycolysis Activation · correlation 0.93
- Actin Vesicle Trafficking · correlation 0.93
- UPR / ER Stress · correlation 0.92
- ER Calcium Stress · correlation 0.91
- ER Protein Processing · correlation 0.90
- ER-Golgi Trafficking · correlation 0.90
- Mitochondrial OxPhos · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.