Actin Cytoskeletal Remodeling
Gene co-expression module in Endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes CFL1 (cofilin-1, actin depolymerization) and ARPC5L (Arp2/3 complex subunit, actin branching) anchor an actin cytoskeletal remodeling program. ACTB and ACTG1 are structural actin isoforms; PFDN2 is a prefoldin chaperone required for actin/tubulin folding; ARF1 regulates actin-dependent vesicle trafficking. Secondary ER quality control genes (ERLEC1, DNAJB11, DNAJC1, SELENOS, LMAN1) are co-expressed, likely reflecting coupled cytoskeletal-ER stress in inflamed endothelium. UBE2N (ubiquitin conjugating enzyme) and CYCS are peripheral members. Mild but significant upregulation in UC and CD inflammation. Neighbor M51 shares ARPC subunits, confirming the actin remodeling neighborhood.
Genes
ACTB, ACTG1, ARF1, ARPC5L, CFL1, CYCS, DNAJB11, DNAJC1, ERLEC1, LMAN1, PFDN2, SELENOS, SUB1, UBE2N
Most correlated modules
- Actin Vesicle Trafficking · correlation 0.91
- ER Calcium Stress · correlation 0.90
- mRNA Splicing Stress · correlation 0.88
- Proteasomal Degradation · correlation 0.88
- Inflammatory Lipid Metabolism · correlation 0.88
- Glycolysis Activation · correlation 0.87
- Rho-Actin Remodeling · correlation 0.87
- ER Protein Processing · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.