mRNA Splicing Stress
Gene co-expression module in Endothelial
| Category | RNA processing & translation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include SRSF9 (SR splicing factor), PPM1G (phosphatase regulating splicing), RTRAF (RNA transcription/export factor), TXNL4A (thioredoxin-like U5 snRNP component), CCDC50 (RNA processing), alongside GLRX3 (glutaredoxin/redox), CCT6A (chaperonin), and YWHAE (14-3-3 scaffold). The dominant program is mRNA splicing and RNA processing, with redox/chaperone support. Significantly upregulated in both UC and CD inflammation, not reversed by treatment, consistent with a stress-activated RNA processing response in inflamed endothelium. Neighbor modules M66 and M54 share the inflammation-upregulation signature and RNA processing themes, confirming a coordinated batch of stress-related RNA programs.
Genes
CCDC50, CCT6A, FAM114A1, GLRX3, PPM1G, RTRAF, SRSF9, TXNL4A, YWHAE
Most correlated modules
- Proteasomal Degradation · correlation 0.93
- ER-Golgi Trafficking · correlation 0.93
- Glycolysis Activation · correlation 0.93
- ER Protein Processing · correlation 0.92
- Actin Vesicle Trafficking · correlation 0.92
- Mitochondrial OxPhos · correlation 0.89
- Actin Cytoskeletal Remodeling · correlation 0.88
- UPR / ER Stress · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.