TMEM88 — Transmembrane protein 88
TMEM88 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM88's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Immediate Early NFkB BCR/AP1/NFKb pathway | ARL5B, CDKN1A, CSRNP1, DUSP2, EGR1, EGR3, IER2, NFKBIA +3 more | View in SCUBA |
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | ABCF1, BCL2A1, BUD23, BZW2, CALR, CEBPZ, DDX21, DENND4A +21 more | View in SCUBA |
| Endothelial | Capillary Endothelial Identity Endothelial cell development | ATOH8, AVPR2, BTNL9, C1QTNF9, CD300LG, CD34, CNFN, FAM13C +10 more | View in SCUBA |
| Pericytes | Pericyte Contractile Tone Cytoskeletal | CARD10, CARD8, EHD4, FAM110D, IL27RA, KANK3, LDB2, NOSTRIN +4 more | View in SCUBA |
About the gene
| Synonyms | FLJ20025, MGC71744 |
|---|---|
| Chromosome | 17: 7855066-7856099 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Wnt signaling pathway |
Function
Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.