ER-Golgi Trafficking
Gene co-expression module in Endothelial
| Category | Protein processing & ER |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes LMAN2, GDI2, RER1, TMED2, TMED9, and RPN2 are all involved in ER-to-Golgi vesicle trafficking and cargo retention. GDI2 regulates Rab GTPases critical for vesicle docking. RALBP1 links Ral GTPase to endocytic trafficking. PSMD1 and CCT8 add proteasomal and chaperonin activity consistent with increased secretory pathway load. Upregulated in IBD inflammation and reversed in remission, consistent with increased secretory/trafficking demand in activated endothelium. Neighbor to M99 which shares ER/Golgi components (KDELR2, COPE), supporting a shared secretory stress program.
Genes
ARPC1A, CCT8, FIBP, GDI2, GGCT, LMAN2, MAP2K2, MRPS16, PAICS, PSMD1, RALBP1, RER1, RPN2, SLC25A3, SNRPE, SYNCRIP, TMED2, TMED9, VKORC1
Most correlated modules
- Glycolysis Activation · correlation 0.96
- mRNA Splicing Stress · correlation 0.93
- ER Protein Processing · correlation 0.92
- Respiratory Chain Complex · correlation 0.92
- Proteasomal Degradation · correlation 0.90
- Mitochondrial OxPhos · correlation 0.89
- Actin Vesicle Trafficking · correlation 0.87
- UPR / ER Stress · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.