Mitochondrial OxPhos
Gene co-expression module in Endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Module splits into two sub-programs: (1) mitochondrial OxPhos — NDUFB2 and NDUFS6 (Complex I subunits), ATP5MF (Complex V), UQCC2 (Complex III assembly factor), AURKAIP1 and SLIRP (mitochondrial ribosome/RNA), all with core/strong membership; (2) actin cytoskeleton — ARPC1B (Arp2/3 complex), PFN1 (profilin), PARVB (parvin/focal adhesion). Neighbor M144 is a pure OxPhos module, supporting the mitochondrial component here. The actin genes may co-vary due to shared inflammatory activation. Given that mitochondrial genes dominate by PageRank and membership, and neighbor M144 is OxPhos, the primary identity is mitochondrial with cytoskeletal admixture.
Genes
ARPC1B, ATP5MF, AURKAIP1, NDUFB2, NDUFS6, PARVB, PFN1, POLR2E, SERF2, SLIRP, TMA7, UQCC2
Most correlated modules
- Mitochondrial OxPhos · correlation 0.95
- ER Protein Processing · correlation 0.93
- Glycolysis Activation · correlation 0.93
- Respiratory Chain Complex · correlation 0.90
- ER-Golgi Trafficking · correlation 0.89
- UPR / ER Stress · correlation 0.89
- Proteasomal Degradation · correlation 0.89
- mRNA Splicing Stress · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.