ER Protein Processing
Gene co-expression module in Endothelial
| Category | Protein processing & ER |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include TXNDC17 (thioredoxin-domain oxidoreductase), ATOX1 (copper chaperone), PPIB (cyclophilin B, ER peptidyl-prolyl isomerase), OSTC (oligosaccharyltransferase complex subunit), SEC61G (ER translocon), and STMP1, alongside metabolic genes ENO1 (glycolysis), SRM (polyamine synthesis), VDAC1 (mitochondrial membrane), and C1QBP (mitochondrial matrix). The module blends ER protein-processing components (PPIB, OSTC, SEC61G, TXNDC17) with general metabolic/housekeeping genes. Uniform expression across subsets and moderate mean expression support a constitutive housekeeping program. Upregulation in inflammation likely reflects increased protein synthesis demand. Neighbors M121 (ER stress/UPR) and M123 (proteasome) share the protein quality control theme; M23 represents the peripheral/constitutive arm of this network rather than the stress-induced UPR core.
Genes
AP2S1, ATOX1, C1QBP, CCT3, DBI, ENO1, NHP2, OSTC, PPIB, SEC61G, SRM, STMP1, TXNDC17, VDAC1
Most correlated modules
- Glycolysis Activation · correlation 0.93
- Mitochondrial OxPhos · correlation 0.93
- ER-Golgi Trafficking · correlation 0.92
- mRNA Splicing Stress · correlation 0.92
- Hypoxia Response · correlation 0.92
- Respiratory Chain Complex · correlation 0.91
- Proteasomal Degradation · correlation 0.90
- UPR / ER Stress · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.