Endothelial NO Activation
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
DDAH2 (dimethylarginine dimethylaminohydrolase 2) degrades ADMA, a competitive inhibitor of eNOS, thereby promoting NO production — a canonical endothelial activation marker. CREM (cAMP response element modulator) is a transcriptional regulator downstream of cAMP/PKA signaling in endothelial activation. CDH13 (T-cadherin/H-cadherin) is an endothelial-enriched adhesion molecule regulating vascular tone and angiogenesis. CD99 facilitates leukocyte transendothelial migration. STMN1 (stathmin) regulates microtubule dynamics during cell activation. VIM (vimentin) and TUBA1A (tubulin) are cytoskeletal components upregulated in activated endothelium. COX5A is a cytochrome c oxidase subunit (mitochondrial). BLOC1S1 is involved in lysosomal biogenesis. SMS (spermine synthase) regulates polyamine metabolism. PTTG1IP is involved in cell signaling. The module is significantly upregulated in IBD inflammation and reflects endothelial NO/cAMP activation signaling.
Genes
BCL6B, BLOC1S1, CD99, CDH13, COX5A, CREM, DDAH2, DDX46, EEA1, EIF5B, LSM7, PTTG1IP, SMS, STMN1, TUBA1A, TUSC3, VIM
Most correlated modules
- Hippo-YAP Cytoskeletal · correlation 0.92
- Rho-Actin Remodeling · correlation 0.84
- Vascular Tone Regulation · correlation 0.83
- Oxidative Stress Response · correlation 0.77
- DNA Damage Repair · correlation 0.74
- Inflammatory Angiogenesis · correlation 0.73
- EC Inflammatory Activation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.