Housekeeping Metabolic
Gene co-expression module in Endothelial
| Category | Housekeeping |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 17 genes have a known function matching the annotation |
Why this annotation
This module contains mitochondrial OxPhos subunits (ATP5MC3, NDUFB7, COX6B1, VDAC3, STOML2) alongside diverse housekeeping genes: CCT5 (chaperonin/protein folding), OAZ1 (ornithine decarboxylase antizyme, polyamine metabolism), RNASEH2C (DNA replication), ERH (RNA processing), ANXA5 (membrane), GSTO1 (glutathione transferase/stress), PIEZO1 (mechanosensing), RAB31 (vesicle trafficking), SSR2 (ER translocon), UBE2I (SUMO E2), CTSL (lysosomal protease), DCTPP1 (nucleotide metabolism). The module is a neighbor of M64 (OxPhos) and shares mitochondrial genes, but is broader and more mixed. The strongest coherent sub-theme is general housekeeping/metabolic activity. Upregulation in inflammation likely reflects increased metabolic activity.
Genes
ANXA5, ATP5MC3, CCT5, COX6B1, CTSL, DCTPP1, ERH, GSTO1, NDUFB7, OAZ1, PIEZO1, RAB31, RNASEH2C, SSR2, STOML2, UBE2I, VDAC3
Most correlated modules
- Respiratory Chain Complex · correlation 0.89
- Mitochondrial OxPhos · correlation 0.88
- Mitochondrial Oxidative Stress · correlation 0.85
- Redox Stress Response · correlation 0.85
- Actin Cytoskeletal Remodeling · correlation 0.83
- Mitochondrial OxPhos · correlation 0.82
- Nuclear Transport · correlation 0.80
- Nuclear Transport · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.