YAP Mechanotransduction
Gene co-expression module in Endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include YAP1 (Hippo/mechanosensing), FLNC and DST (cytoskeletal linkers), COBLL1 (actin cytoskeleton), FN1 and THSD4 (ECM), and SYT1/STX7 (vesicle trafficking). The co-expression of YAP1 with cytoskeletal tension genes (FLNC, DST, COBLL1, TLN-related) and ECM components (FN1, THSD4, FGL2) is characteristic of a mechanotransduction/YAP-Hippo signaling program in endothelial cells responding to mechanical stimuli. DEPP1 is a FOXO/stress target. Low expression and uniform distribution suggest a subpopulation-specific or low-activity state. Neighbor M130 also involves ECM remodeling, supporting a structural/remodeling neighborhood.
Genes
COBLL1, CREB5, DEPP1, DST, FGL2, FLNC, FN1, GCNT2, GLIPR2, IGF2, MEDAG, STX7, SYT1, THSD4, TMEM120A, YAP1
Most correlated modules
- Arterial EC Identity · correlation 0.85
- Arterial EC Identity · correlation 0.73
- Inflammatory ECM Remodeling · correlation 0.73
- Inflammatory Angiogenesis · correlation 0.69
- Endothelial Quiescence · correlation 0.63
- Arterial EC Homeostasis · correlation 0.58
- TGF-beta ECM Remodeling · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.