EC Cytoskeletal Scaffold
Gene co-expression module in Endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes VAV3 (Rho/Rac GEF, actin cytoskeleton regulation), SYNM (synemin, intermediate filament crosslinker), ADD3 (adducin, actin-spectrin cytoskeleton), EPB41L2 (band 4.1L2, membrane-cytoskeleton linker), GYPC (glycophorin C, membrane skeleton anchor), RECK (MMP inhibitor, ECM-cytoskeleton interface), and NRP2 (neuropilin-2, cytoskeletal signaling in ECs) collectively define a cytoskeletal scaffolding and membrane integrity program. The module decreases in UC inflammation and recovers in remission, consistent with loss of EC structural integrity during active disease. ANTXR2 (anthrax toxin receptor 2) also links to actin cytoskeleton.
Genes
ADD3, ANTXR2, CTSD, EPB41L2, FXYD6, GYPC, MAP4K2, NRP2, RECK, SYNM, VAV3
Most correlated modules
- Venous EC Identity · correlation 0.84
- Actomyosin Contractility · correlation 0.77
- Inflammatory Angiogenesis · correlation 0.76
- TGF-beta ECM Remodeling · correlation 0.71
- Venous EC Identity · correlation 0.68
- Inflammatory EC Activation · correlation 0.67
- Arterial EC Identity · correlation 0.64
- Inflammatory ECM Remodeling · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.