TLE1 — TLE family member 1, transcriptional corepressor
TLE1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TLE1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation signaling B cell maturation | ANKRD44, BLK, BTN3A2, EVI2B, GAPT, GPSM3, LBH, LTB +9 more | View in SCUBA |
| CD4⁺ T cells | Th17/MAIT type-17 Th17 fate | AKT1S1, CA10, CA2, CCL20, CEBPD, GFPT2, IL22, IL4I1 +9 more | View in SCUBA |
| Endothelial | Arterial EC Identity Endothelial cell development | CCDC71L, FABP4, LAPTM5, MAP3K1, MDK, PCBD1, PMVK, RASSF4 +2 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Repression DNA/chromatin regulation | CAPN12, CFAP210, CNOT10, EPS8L2, FKBP5, H1-10, HAGHL, IL6ST +8 more | |
| Innate lymphoid cells | Inflammasome Activation Inflammation | ANKRD28, AP3D1, ARHGEF7, CCNH, CD55, CDC42SE1, CHD7, CHKA +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | MAIT Cell Identity T cell maturation | AFF3, DDX3Y, DKK3, DSE, EPAS1, FKBP5, FYN, GLIPR1 +16 more | |
| Natural Killer cells | Inflammatory Stress Response Stress | AKIRIN2, CCNH, CEBPD, CLASP1, FKBP5, H3C1, P2RX5, PARP8 +2 more | View in SCUBA |
About the gene
| Synonyms | ESG, ESG1, GRG1, TLE-1 |
|---|---|
| Chromosome | 9: 81583683-81689547 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF- 1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.