Wnt Angiogenic Remodeling
Gene co-expression module in Endothelial
| Category | ECM remodeling |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
This module has the strongest inflammation delta in the batch (0.72 UC, 0.65 CD) with strong remission reversal (-0.54), indicating a highly inflammation-specific program. LEF1 is a canonical Wnt/β-catenin transcription factor. RCAN1 is a VEGF/calcineurin-regulated gene critical for angiogenesis. ADAMTS4 is an ECM-remodeling protease upregulated in inflamed endothelium. POSTN (periostin) is an ECM protein associated with tissue remodeling. MTHFD2 is a one-carbon metabolism enzyme upregulated in proliferating/activated endothelial cells. IL4R mediates IL-4 signaling in endothelial cells. FKBP11 is an ER immunophilin. UCK2 and UPP1 reflect nucleotide metabolic reprogramming. ADGRL2 is an adhesion GPCR. Together, LEF1+RCAN1+ADAMTS4+POSTN define a Wnt-driven angiogenic/ECM remodeling program activated in IBD inflammation.
Genes
ADAMTS4, ADGRL2, BAZ1A, FKBP11, IL4R, LDLRAD3, LEF1, MTHFD2, NEURL1B, PABPC1, POSTN, RCAN1, UCK2, UPP1
Most correlated modules
- NF-κB Endothelial Activation · correlation 0.86
- Inflammatory Endothelial Activation · correlation 0.85
- NF-κB Oxidative Stress · correlation 0.81
- Procoagulant TGF-β Response · correlation 0.80
- Stress RNA Processing · correlation 0.80
- Hypoxia Response · correlation 0.80
- Leukocyte Recruitment Signaling · correlation 0.71
- Endothelial Quiescence Identity · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.