Spliceosome snRNP Assembly
Gene co-expression module in Endothelial
| Category | RNA processing & translation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes CCT4 and CCT2 are subunits of the TRiC/CCT chaperonin complex. SNRPB and SNRPF are core snRNP spliceosome components; HNRNPC and HNRNPAB are heterogeneous nuclear ribonucleoproteins; NONO is a nuclear RNA-binding paraspeckle protein; RBM3 is a cold-shock RNA-binding protein. EIF3I and SRP19 support translation/co-translational targeting. NAP1L1 is a histone/nucleosome chaperone; CBX3 (HP1γ) is a chromatin regulator. BAX adds an apoptotic signal. FGFR1 and YWHAQ are peripheral. The module is dominated by spliceosome snRNP components and chaperonin activity, upregulated in UC and CD inflammation. Compared to neighbor M4 (broader splicing/redox), M54 is more specifically focused on snRNP spliceosome assembly supported by TRiC chaperonins.
Genes
BAX, CBX3, CCT2, CCT4, EIF3I, FGFR1, HNRNPAB, HNRNPC, NAP1L1, NONO, RBM3, SNRPB, SNRPF, SRP19, YWHAQ
Most correlated modules
- Nuclear Transport · correlation 0.88
- mRNA Splicing · correlation 0.87
- mRNA Splicing Stress · correlation 0.86
- NF-κB Oxidative Stress · correlation 0.85
- ER-Golgi Trafficking · correlation 0.85
- Glycolysis Activation · correlation 0.83
- Actin Cytoskeletal Remodeling · correlation 0.83
- Respiratory Chain Complex · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.