MAP3K13 — Mitogen-activated protein kinase kinase kinase 13
MAP3K13 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAP3K13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TRIM28-ZNF Repression DNA/chromatin regulation | B4GALT4, EEA1, FSCN1, HSPA2, ISG20L2, MLF1, MORN3, PABPC4 +7 more | View in SCUBA |
| Endothelial | Stress RNA Processing RNA processing & translation | ARF4, CACYBP, ELOC, ENY2, EWSR1, GNA14, HNRNPDL, HNRNPF +5 more | View in SCUBA |
About the gene
| Synonyms | LZK, MEKK13 |
|---|---|
| Chromosome | 3: 185282941-185489094 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.