CLDN4 — Claudin 4
CLDN4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLDN4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | EGFR wound response Epithelial development | DDX60L, ERRFI1, GPRC5A, KLF6, SNX9, STOM | View in SCUBA |
| Goblet cells | Goblet Cell Differentiation Epithelial development | EIF1, ELF3, KLF3, KLF4, MIDN, PPP1R15A, RAB11FIP1, TOB1 | View in SCUBA |
About the gene
| Synonyms | CPE-R, CPETR, CPETR1, hCPE-R, WBSCR8 |
|---|---|
| Chromosome | 7: 73799542-73832690 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Chloride channel, Ion channel |
| Biological process | Ion transport, Transport |
Function
Can associate with other claudins to regulate tight junction structural and functional strand dynamics. May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity). May integrate into CLDN3 strands to modulate localized tight junction barrier properties. May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance. Cannot form tight junction strands on its own.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.