Colonocyte differentiation signaling
Gene co-expression module in Enterocytes
| Category | Epithelial development |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
This module mixes signaling and trafficking genes: CRACD, TNIK (Wnt signaling), DENND5B, RALGPS1, NEDD4 and APPL2. CA13 and BTNL8 are enterocyte-specific; BTNL8 regulates intraepithelial gamma-delta T cells. The pattern is most consistent with a colonocyte differentiation state with polarized vesicle trafficking. Coherence is core but the program is not well defined, so certainty is low.
Genes
APPL2, BTBD9, BTNL8, CA13, CRACD, DENND5B, LUZP1, NEDD4, RALGPS1, SEMA6D, TNIK
Most correlated modules
- Mature colonocyte brush-border · correlation 0.87
- Brush-border enterocyte · correlation 0.85
- Sterol Transfer · correlation 0.84
- Chylomicron lipid absorption · correlation 0.83
- Apical Na+/H+ transport · correlation 0.83
- Epithelial junction polarity · correlation 0.82
- Enterocyte fatty-acid catabolism · correlation 0.82
- Apical junction complex · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.