RAPGEF5 — Rap guanine nucleotide exchange factor 5
RAPGEF5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAPGEF5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Dark-zone GC B-cell B cell maturation | BRWD1, CCDC144A, CCDC88A, CD38, FGD6, LPP, MYBL1, MYO1E +2 more | View in SCUBA |
| Enterocytes | Apicobasal polarity scaffold Migration & adhesion | ADGRG7, CAMK2D, DPYD, MAGI3, MAST2, MGAM2, NUMB, PATJ +3 more | View in SCUBA |
| Smooth muscle cells | Pericyte Signature Development | AC100803.3, CCND1, COX4I2, CPM, ENTPD3, GPR20, GPRIN3, GRIP2 +8 more | View in SCUBA |
About the gene
| Synonyms | GFR, KIAA0277, MR-GEF |
|---|---|
| Chromosome | 7: 22118236-22357154 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.