TCF12 — Transcription factor 12
TCF12 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TCF12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Apicobasal polarity scaffold Migration & adhesion | ADGRG7, CAMK2D, DPYD, MAGI3, MAST2, MGAM2, NUMB, PATJ +3 more | View in SCUBA |
| Lymphatic endothelial | Focal Adhesion Migration migration & adhesion | BIRC6, CDC42BPA, DOCK1, EIF4G3, GNAQ, LPP, NF1, PAM +2 more | View in SCUBA |
| Macrophages | Endosomal Rab Trafficking Vesicular traficking | ABL1, ANKS1A, ARB2A, CAMK1D, CPEB3, DENND4C, DISC1, FBXL17 +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Survival T cell maturation | ARHGEF3, BTN3A1, CNTRL, GIMAP8, ME2, PCMTD1, PRKACB, RSBN1L +4 more | |
| Neutrophils | Myeloid Lipid Remodeling Developmental | ADK, AGPS, ATP8A1, ATP8B4, CLTCL1, DOP1B, ERG, GPD2 +3 more |
About the gene
| Synonyms | bHLHb20, HEB, HsT17266, HTF4, p64 |
|---|---|
| Chromosome | 15: 56918623-57299281 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, DNA-binding |
| Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Function
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.