SORBS2 — Sorbin and SH3 domain containing 2
SORBS2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SORBS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | NF-kB Chromatin Regulation DNA/chromatin regulation | ARHGEF3, DGKE, HLA-E, HOXB3, IKBKB, ITPKB, KITLG, LIMCH1 +4 more | View in SCUBA |
| Enterocytes | Spectrin-actin scaffold Cytoskeletal | ADD3, DEPTOR, DNAAF9, FYB2, MBOAT2, PRKCB, SETBP1, SIPA1L2 +2 more | View in SCUBA |
| Fibroblasts | ICC neuromuscular junction Gut motility | ATP1A2, ATRNL1, CASQ2, COL19A1, CTNNA3, FAM83D, KCNIP4, LRRC7 +6 more | View in SCUBA |
| Glial cells | Glial Adhesion Cytoskeletal migration & adhesion | AKAP9, COL21A1, DOCK5, EPB41L2, KIAA1217, LTBP3, NCAM1, RALGPS2 +1 more | View in SCUBA |
| Smooth muscle cells | Vascular SMC Identity Contractility | ADIRF, ARPC1A, BCAM, CCDC3, CRIP1, EFHD1, GPRC5C, GPX3 +10 more | View in SCUBA |
About the gene
| Synonyms | ARGBP2, KIAA0777 |
|---|---|
| Chromosome | 4: 185585444-185956652 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.