MBOAT2 — Membrane bound O-acyltransferase domain containing 2
MBOAT2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MBOAT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | ACTN1, AK4, CCL14, CTTNBP2, DAPK1, EPB41L3, FAM171A1, IL1R1 +18 more | View in SCUBA |
| Enterocytes | Spectrin-actin scaffold Cytoskeletal | ADD3, DEPTOR, DNAAF9, FYB2, PRKCB, SETBP1, SIPA1L2, SNTB1 +2 more | View in SCUBA |
| Hematopoietic progenitor cells | Hematopoietic Progenitor Identity Stemness | CD38, DAD1, HSH2D, HYAL3, ITGAE, KIT, MTHFD2, PARVB +2 more |
About the gene
| Synonyms | FLJ14415, FLJ90298, LPLAT13, OACT2 |
|---|---|
| Chromosome | 2: 8852690-9003709 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Function
Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Catalyzes preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS). Prefers oleoyl-CoA as the acyl donor. May be involved in chondrocyte differentiation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.