SUCLG1 — Succinate-CoA ligase GDP/ADP-forming subunit alpha
SUCLG1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SUCLG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Enterocyte Ion/Nutrient Transport Absorption | AKR1A1, AKR7A3, CALM1, CHP2, CLDN15, FCGRT, LGALS2, MGAT4B +2 more | View in SCUBA |
| Gamma-delta T cells | Mitoribosome Small Subunit Mitochondrial & OxPhos | ACADM, C14orf119, CHCHD1, COA3, COA4, COMMD8, GALK1, GEMIN6 +24 more | |
| Goblet cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ATP5F1B, ATP5PB, CD99, COTL1, ECHS1, GPR160, HADH, PRDX3 +1 more | View in SCUBA |
| Innate lymphoid cells | Proteasome & TCA Protein processing & ER | ACP1, ARPC5L, CAPZA1, CLTA, COPS9, HDAC1, MDH2, NDUFA1 +5 more | View in SCUBA |
| Macrophages | Complex I / NADH Dehydrogenase Mitochondrial & OxPhos | AHCY, ANP32A, ANTKMT, APEX1, ARL2, ATIC, ATP5F1A, ATP5ME +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARFRP1, ARL2, ATP6V0E1, CALHM2, CCS, COA4, DBP, DENND2D +15 more |
About the gene
| Chromosome | 2: 84423528-84460045 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Ligase |
| Biological process | Tricarboxylic acid cycle |
Function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.