Long-gene Nuclear Transcripts
Gene co-expression module in Enterocytes
| Category | Technical artifact |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 13 of 15 genes have a known function matching the annotation |
Why this annotation
The module is dominated by very long, intron-rich genes with uniform expression and no coherent functional theme: ABCA10, ABCA5, MAGI1, INSR, NFATC3, ADCY9, STAU2, MBNL1, GABRA2, SEMA6A, EXOC6B, IL6R and RRAS2. This pattern is typical of nuclear pre-mRNA/long-gene capture, a technical axis rather than a single program. It neighbors the similar long-gene module M17.
Genes
ABCA10, ABCA5, ADCY9, EXOC6B, GABRA2, IL6R, INSR, MAGI1, MBNL1, NFATC3, RRAS2, SEMA6A, SLC17A4, STAU2, TCP11L1
Most correlated modules
- Mature enterocyte differentiation · correlation 0.85
- Villus-tip enterocyte transport · correlation 0.82
- Sterol Transfer · correlation 0.81
- Brush-border Nutrient Uptake · correlation 0.81
- Colonocyte Solute Transport · correlation 0.81
- ER-autophagy homeostasis · correlation 0.80
- Colonocyte differentiation TFs · correlation 0.78
- Crypt-top colonocyte · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.