SEMA6A — Semaphorin 6A
SEMA6A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEMA6A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | ACTN1, AK4, CCL14, CTTNBP2, DAPK1, EPB41L3, FAM171A1, IL1R1 +18 more | View in SCUBA |
| Enterocytes | Long-gene Nuclear Transcripts Technical artifact | ABCA10, ABCA5, ADCY9, EXOC6B, GABRA2, IL6R, INSR, MAGI1 +6 more | View in SCUBA |
| Goblet cells | Colonocyte Metabolic Defense Mitochondrial & OxPhos | ACAA2, CAT, CRYBG1, GLIPR2, MLXIP, PKDCC, SAMD5, ZFHX3 | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Development Valve formation | GPM6A, LRP5, MEF2C, MPP7, NFIA, NFIB, PGM5, PRKAR1B +5 more | View in SCUBA |
| Pericytes | BMP-SMAD Signaling Developmental | CTSH, ETS2, EXOC3L2, IL3RA, ITM2A, MCF2L, NDST1, PDE2A +3 more | View in SCUBA |
About the gene
| Synonyms | HT018, KIAA1368, SEMA, SEMA6A1, SEMAQ |
|---|---|
| Chromosome | 5: 116443555-116574823 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Neurogenesis |
Function
Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.