Long-gene nuclear transcripts
Gene co-expression module in Enterocytes
| Category | Technical artifact |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 15 genes have a known function matching the annotation |
Why this annotation
The module is dominated by extremely long genes, including the fragile-site genes FHIT and WWOX, plus PTPRK, LRBA, NBEAL1, ARL15, LDLRAD4, CERS6, EXT1, MLLT3, KANK1 and NHSL1. It is broadly detected (88% of cells) and uniform across subsets. This is the classic signature of intronic or nuclear read capture scaling with gene length. NR5A2 and FUT8 add some epithelial identity but do not define a program. It co-varies with the other long-gene neighbors in this batch.
Genes
ARL15, BLNK, CERS6, EXT1, FHIT, FUT8, KANK1, LDLRAD4, LRBA, MLLT3, NBEAL1, NHSL1, NR5A2, PTPRK, WWOX
Most correlated modules
- Long-gene nuclear transcripts · correlation 0.81
- Long-gene nuclear transcripts · correlation 0.79
- Enterocyte identity TFs · correlation 0.73
- Apicobasal polarity · correlation 0.69
- Serotonergic receptor signaling · correlation 0.69
- Apicobasal polarity scaffold · correlation 0.60
- Mature enterocyte transport · correlation 0.59
- Mitochondrial Energy Metabolism · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.