WTAP — WT1 associated protein

WTAP belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

WTAP's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	TCR Activation Signaling TCR/AP1/NFKb pathway	AKNA, ATP6V1A, BCL2L11, KIF20B, LAX1, NAA50, NEDD9, NPC1 +6 more	View in SCUBA
Fibroblasts	Hypoxia Metabolic Stress Stress	ABL2, DYRK3, EMP1, ERRFI1, HMOX1, NFATC1, PFKFB3, PIM1 +3 more	View in SCUBA
Gamma-delta T cells	mRNA Splicing Regulation RNA processing & translation	ARF6, BTG3, CAPN7, CDV3, CELF2, CNBD2, CUL3, CYTIP +18 more
Glial cells	NF-κB/IFN Inflammatory Inflammation	BIRC3, CTSS, CXCL10, CXCL2, CXCL9, FDCSP, HAPLN3, ICAM1 +4 more	View in SCUBA
Lymphatic endothelial	NF-κB Autophagy Regulation Immune regulation	CLIC2, GABARAPL1, LGMN, NFKBIB, OSER1, PRRG4, RELB, RNF114 +3 more	View in SCUBA
Macrophages	NF-κB AP-1 Signaling Inflammatory	ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more	View in SCUBA
Monocytes	NF-κB Signaling Inflammatory	BIRC3, ERN1, G0S2, ICAM1, IER3, IRAK2, NFKB1, PDE4B +4 more	View in SCUBA
Mucosal-associated invariant T cell	RNA Splicing m6A RNA processing & translation	ARF1, ARF6, ATP5F1B, CIRBP, CORO7, EIF1B, EIF5A, EMD +15 more

About the gene

Synonyms	KIAA0105, MGC3925, Mum2
Chromosome	6: 159725585-159756319
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Predicted intracellular proteins
Molecular function	Developmental protein
Biological process	Cell cycle, mRNA processing, mRNA splicing

Function

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.