NF-κB Epigenetic Reprogramming
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
REL (c-Rel, NF-κB subunit) and BCL3 (IκB-like NF-κB co-activator) are NF-κB pathway components. KDM6B (JMJD3) is an H3K27me3 demethylase strongly induced by NF-κB/inflammatory signals to epigenetically activate inflammatory gene programs. CSRNP1 is an immediate early stress/inflammatory TF. KLF10 (TIEG1) is a TGF-β/stress-responsive Krüppel-like factor. CDKN1A (p21) mediates cytokine-induced growth arrest. DUSP5 is an ERK phosphatase induced by growth factors and inflammatory signals. MYC is a proliferation/stress TF. EGR2 is an immediate early TF induced by inflammatory signals. BTG2 is an anti-proliferative immediate early gene. LDLR and MYADM are metabolic/membrane genes with inflammatory regulation. The module represents NF-κB-driven transcriptional and epigenetic reprogramming with growth arrest, distinct from the pure immediate early program of M102.
Genes
BCL3, BTG2, CDKN1A, CSRNP1, DUSP5, EGR2, KDM6B, KLF10, LDLR, MYADM, MYC, REL
Most correlated modules
- Proteotoxic Stress Survival · correlation 0.91
- Integrated Stress Response · correlation 0.89
- Heat Shock Response · correlation 0.86
- NF-κB Immediate Early · correlation 0.82
- BMP-ID Stress Response · correlation 0.82
- NF-κB Stress Response · correlation 0.76
- Hypoxia Metabolic Stress · correlation 0.75
- Unfolded Protein Response · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.