ZBTB21 — Zinc finger and BTB domain containing 21
ZBTB21 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZBTB21's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Immediate early response BCR/AP1/NFKb pathway | CCNT1, CREM, HES4, JMY, JOSD1, KDM4B, NR4A3, PCNX4 +7 more | View in SCUBA |
| CD4⁺ T cells | TCR early activation TCR/AP1/NFKb pathway | ARIH1, BRAF, CCNT1, CLEC2D, ELL2, EMD, FAM133B, FOSL2 +11 more | View in SCUBA |
| Fibroblasts | Hypoxia Metabolic Stress Stress | ABL2, DYRK3, EMP1, ERRFI1, HMOX1, NFATC1, PFKFB3, PIM1 +3 more | View in SCUBA |
| Gamma-delta T cells | NF-κB Activation Inflammation | DUSP5, GADD45A, HERPUD1, IL21R, KDM6B, MAFF, NAMPT, NFKB1 +13 more | |
| Mucosal-associated invariant T cell | Splicing Regulation RNA processing & translation | AREG, ARHGAP9, AZIN1, CCNH, CLK1, DDX24, DNAJB6, IL23R +9 more |
About the gene
| Synonyms | KIAA1227, ZNF295 |
|---|---|
| Chromosome | 21: 41986831-42010387 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Acts as a transcription repressor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.