TOX — Thymocyte selection associated high mobility group box
TOX belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TOX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Ras signaling BCR/AP1/NFKb pathway | ANKRD28, CCL5, DOK3, GSTK1, GYPC, HOPX, HSH2D, ITGAM +12 more | View in SCUBA |
| CD4⁺ T cells | Tfh program B cell help | BAZ2B, CCDC50, CDK5R1, CXCR5, IL6R, LY96, MTUS1, PASK +10 more | View in SCUBA |
| CD8⁺ T cells | Tumor mediated exhaustion Exhaustion | ANXA6, CXCL13, GALM, HNRNPLL, IFNG, ITM2A, PDCD1, PTPN7 +3 more | View in SCUBA |
| Fibroblasts | Intestinal Fibroblast Identity Developmental | ABR, AFF3, ATP8A1, ATP9A, CAMK4, DSE, ENPP2, GLP2R +7 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | AKAP5, AOAH, CCDC141, CD8A, CD8B, CDYL, CRTAM, CYSTM1 +20 more | |
| Innate lymphoid cells | ILC Transcription Factor Program Differentiation | APP, DCTN2, DEF6, GRAMD1A, GRHPR, HSD17B12, HSPB1, ILK +11 more | View in SCUBA |
About the gene
| Synonyms | KIAA0808, TOX1 |
|---|---|
| Chromosome | 8: 58805412-59119147 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator, DNA-binding |
| Biological process | Neurogenesis, Transcription, Transcription regulation |
Function
Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (By similarity). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (By similarity). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC) (By similarity). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (By similarity). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation- induced cell death (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.