TNFRSF10B — TNF receptor superfamily member 10b
TNFRSF10B belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFRSF10B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mixed Metabolic Ambient Technical artifact | DPYD, ENO2, FABP6, FCGRT, GRAP, SMURF2, SPINK2, SYNJ2BP +1 more | View in SCUBA |
| Endothelial | NF-κB Endothelial Activation Inflammation | LITAF, NAMPT, NFKB2, NUAK2, RELB, SBNO2, SELE, SLC35F2 +5 more | View in SCUBA |
| Fibroblasts | ER Stress UPR Stress | ARF4, B4GALT1, BTG3, BZW1, CYCS, EFHD2, ELOC, LDHA +6 more | View in SCUBA |
| Lymphatic endothelial | DNA Damage Apoptosis DNA/chromatin regulation | AZIN1, BAZ1A, HNRNPC, IVNS1ABP, MAPK6, OTUD4, PHLDB2, SPEN +4 more | View in SCUBA |
About the gene
| Synonyms | CD262, DR5, KILLER, TRAIL-R2, TRAILR2, TRICK2A, TRICKB |
|---|---|
| Chromosome | 8: 23020133-23069031 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Apoptosis |
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.