SEMA3D — Semaphorin 3D
SEMA3D belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEMA3D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Wnt-Niche Fibroblast Developmental | AHNAK, AHNAK2, AKAP12, CELF2, CYSLTR1, DPYSL3, DST, GAS6 +10 more | View in SCUBA |
| Lymphatic endothelial | Actomyosin Contractility Cytoskeletal | AFAP1L1, C1orf21, COBLL1, EEA1, GNB1, MAP4, OSBPL8, PPP1R12A +6 more | View in SCUBA |
| Smooth muscle cells | Wnt-Hedgehog Niche Development | ADGRL3, APOC1, CLMP, CMIP, EDNRB, HSD17B6, IRS1, LTBP3 +8 more | View in SCUBA |
About the gene
| Synonyms | coll-2, Sema-Z2 |
|---|---|
| Chromosome | 7: 84995553-85187056 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Neurogenesis |
Function
Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.