RBPMS — RNA binding protein, mRNA processing factor
RBPMS belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RBPMS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Membrane Transport Endothelial cell development | AQP1, CDH24, CEBPG, CLIC5, FAP, LSM6, OIT3, OSTF1 +9 more | View in SCUBA |
| Fibroblasts | Telocyte Identity Program Developmental | ADGRL3, ANKRD50, ARHGAP28, CLSTN2, FBLN7, FOXF1, LAMA4, PDIA5 +10 more | View in SCUBA |
| Hematopoietic progenitor cells | Quiescent HSC State Stemness | ARHGEF17, BAALC, BIN1, CD52, GNAI1, HOPX, MZB1, SPINK2 | |
| Smooth muscle cells | SMC focal adhesion Migration & adhesion | ANXA6, ARMCX6, C1orf21, CD99, DNAJC1, HSBP1, KANK1, MORF4L2 +7 more | View in SCUBA |
About the gene
| Synonyms | HERMES |
|---|---|
| Chromosome | 8: 30384511-30572256 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator, RNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
RNA binding protein that mediates the regulation of pre-mRNA alternative splicing (AS). Acts either as activator (FLNB, HSPG2, LIPA1, MYOCD, PTPRF and PPFIBP1) or repressor (TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1 and MBML2) of splicing events on specific pre-mRNA targets (By similarity). Together with RNA binding proteins RBFOX2 and MBNL1/2, activates a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of numerous pre- mRNA involved in actin cytoskeleton and focal adhesion machineries, suggesting a role in promoting a cell differentiated state (By similarity). Binds to introns, exons and 3'-UTR associated with tandem CAC trinucleotide motifs separated by a variable spacer region, at a minimum as a dimer. The minimal length of RNA required for RBPMS- binding tandem CAC motifs is 15 nt, with spacing ranging from 1 to 9 nt. Can also bind to CA dinucleotide repeats. Mediates repression of TPM1 exon 3 by binding to CAC tandem repeats in the flanking intronic regions, followed by higher- order oligomerization and heterotypic interactions with other splicing regulators including MBNL1 and RBFOX2, which prevents assembly of ATP- dependent splicing complexes (By similarity). Acts as a regulator of pre-mRNA alternative splicing (AS) (By similarity). Binds mRNA. Regulates AS of ACTN1, FLNB, although with lower efficiency than isoform A / RBPMSA (By similarity). Acts as coactivator of SMAD transcriptional activity in a TGFB1-dependent manner, possibly through increased phosphorylation of SMAD2 and SMAD3 at the C-terminal SSXS regions and promotion of the nuclear accumulation of SMAD proteins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.