WASF2 — WASP family member 2
WASF2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
WASF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Lysosomal Cytoskeletal Vesicular traficking | C7orf50, FBXO21, LHFPL6, MAGED2, PLS3, PPT1, SCPEP1, SDC2 +1 more | View in SCUBA |
| Innate lymphoid cells | Centrosome & Scaffolding Cytoskeleton & motility | AKAP9, APPL1, ARID4A, CCDC91, CPNE3, ETNK1, FAM204A, GOPC +14 more | View in SCUBA |
| Macrophages | Mixed Regulatory Signaling Housekeeping | ADAP2, AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2 +30 more | View in SCUBA |
| Mucosal-associated invariant T cell | Integrin Actin Adhesion migration & adhesion | ACTR2, ANKRD10, ATP2B1, DDX46, HP1BP3, HPS3, JAK1, LINS1 +11 more | |
| Pericytes | ER-Actin Cytoskeletal Cytoskeletal | A2M, CSDE1, GTF2I, IQGAP1, KTN1, MAP4K4, SEC62, SERINC1 | View in SCUBA |
| Smooth muscle cells | Actin Cytoskeletal Scaffold Cytoskeletal | ACTN4, ATP2B4, ATRX, DDX5, DLGAP4, EIF4G2, FAT1, GNAI2 +13 more | View in SCUBA |
About the gene
| Synonyms | SCAR2, WAVE2 |
|---|---|
| Chromosome | 1: 27404230-27490167 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Actin-binding |
| Biological process | Host-virus interaction |
Function
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.