PPT1 — Palmitoyl-protein thioesterase 1
PPT1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Lysosomal Cytoskeletal Vesicular traficking | C7orf50, FBXO21, LHFPL6, MAGED2, PLS3, SCPEP1, SDC2, TTC3 +1 more | View in SCUBA |
| Gamma-delta T cells | Nuclear Pore Organization Housekeeping | AIDA, DHX8, H4C6, LARP1, LBR, MPRIP, MTR, NNT +14 more | |
| Macrophages | Oxidative Metabolic Program Mitochondrial & OxPhos | ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D +29 more | View in SCUBA |
About the gene
| Synonyms | CLN1, INCL, PPT |
|---|---|
| Chromosome | 1: 40072710-40097260 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Sensory transduction, Vision |
Function
Has thioesterase activity against fatty acid thioesters with 14 -18 carbons, including palmitoyl-CoA, S-palmitoyl-N- acetylcysteamine, and palmitoylated proteins. In contrast to PPT2, PPT1 can hydrolyze palmitoylated proteins and palmitoylcysteine.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.